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Tumor-Adjacent Dendritic Cells Crucial for Cancer Growth in T-Cell Leukemia

Jul 13, 2016 1:00:11 PM / by Steffen Porwollik posted in leukemia, stromal cells, T Cells, T lymphocytes, Tumors, white blood cells, Basic Research

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Scientists examine the effect of the tumor microenvironment on cancer fate in acute lymphocytic leukemia (ALL), a disease prevalent in young children. They find that the tumor-adjacent dendritic cells provide essential cues for cancer growth.

For the past fifty years, the incidence of acute lymphocytic leukemia (ALL), a cancer of immature white blood cells, has been rising steadily. Currently, about 6,500 new cases occur annually in the US. The onset of the wretched disease is most common in early childhood, between ages 2 and 5, but can also happen later in life. Luckily, modern chemotherapy and stem cell approaches have resulted in a substantial increase in the 5-year survival rate for children affected by the disease, to over 75%. However, outlook remains poor for those that do not respond well to these therapies. As is the case for the disease’s chronic counterpart, CLL, more treatment options are sorely needed (as we recently reported).

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Allergy Thumbs a Ride During Transplantation of Hematopoietic Stem Cells

May 11, 2016 1:00:16 PM / by Steffen Porwollik posted in Bone Marrow, food allergy, leukemia, PBMCs, Stem Cell Therapy, Stem Cells, Basic Research

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German scientists prove that the kiwifruit allergy in a male patient was caused by the transplantation of his sister’s hematopoietic stem cells. Obtaining a stem cell donor’s allergy profile prior to such surgeries may be a small effort worth its while.
 

He may have loved to eat kiwifruit. He may have been indifferent towards the fuzzy green egg-shaped things. He may not have liked them at all. But, whatever his attitude towards the innocent-looking berries was, he was not allergic to them. That is, until, at age 26, he needed a bone marrow transplant to battle acute lymphocytic leukemia. His sister turned out to be a matching donor, and the transplantation was a success. It kept the leukemia in check.

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Learning from Stem Cells Modeling Leukemia in a Dish

Nov 9, 2015 1:00:57 PM / by Daisy posted in leukemia, Stem Cells, Basic Research

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Researchers use skin cells from pediatric patients and program them into stem cells to investigate molecular mechanisms for rare form of childhood leukemia

Juvenile myelomonocytic leukemia (JMML) is diagnosed in children whose average age at diagnosis is two. Hematopoietic stem cell transplantation can cure some patients but not all. On the other end, minimal treatment -- or none at all -- can also result in remission. How does one decide how to treat JMML patients?

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CAR T Cells, Little Steps, Huge Progress

Oct 14, 2015 1:00:51 PM / by Daisy posted in CAR-T, clinical trial, leukemia, Basic Research, Immunotherapy (Immunology)

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Therapeutic CAR T cells administered to leukemia patients in a clinical trial offer long remissions associated with T cells that persist out to at least 4 years

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Improved Outcome for Stem Cell Transplantation in Leukemia

Sep 28, 2015 1:00:14 PM / by Daisy posted in GVHD, Bone Marrow, clinical trial, leukemia, Stem Cells, T Cells, Basic Research

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About 50% of stem cell transplant patients develop GVHD. A clinical trial using a modified stem cell graft reduced this hazard to 9%.

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