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Tests in New Immunotherapy Targets Macrophages Instead of Cancer Cells

Dec 23, 2019 10:07:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Cancer, Macrophages, Immunotherapy (Immunology)

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A collaborative team of scientists from Denmark, France, the UK, and the US recognized the potential to target CD163 macrophages for a novel approach to cancer immunotherapy.

Macrophages are one of many types of immune system cells of the body, and they function to phagocytize and digest invading substances including bacteria and other microorganisms; they also digest cellular debris and cancer cells. However, there are a subset of macrophages (CD163 macrophages) that actually supports tumor survival and impedes T-cell attack of tumors. Expression of CD163 by these macrophages is associated with a poorer prognosis for a number of human cancers, such as malignant melanoma.

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Stem Cell-Like Function of Adult Immune Cells Stimulate Healing

Apr 9, 2018 10:05:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Macrophages, Stem Cells, immune cells

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New research suggests that wound fluid induced macrophage clustering shows improved healing.

Tissue damage is repaired by the proliferation of normal cells, tissue stem cell maturation, and scar formation. However, the inflammation associated with tissue damage or injury promotes cell plasticity as part of the tissue repair process. Fibroblasts that are critical for wound healing are mesenchymal cells that are actually derived from myeloid cells such as macrophages. Macrophages are immune cells that are the first line of defense against pathogens. They are also important in wound healing and inflammatory processes.

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Cancer Treatment That Boosts Macrophage Cancer-Fighting Action

Mar 22, 2017 3:21:32 PM / by Stacy Matthews Branch, DVM, PhD posted in Cancer, Cytotoxic T Cells, Macrophages

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Many therapeutic strategies are continuously being investigated to find the means to effectively treat cancer. Immunotherapeutic approaches are emerging as very valuable options for patients with different types of cancer. Many of the approaches involve targeting the adaptive immune system. The adaptive immune system involves targeting specifically identified cells by cytotoxic T cells and represents a specialized attack on invading and pathogenic (disease-causing) cells and molecules.

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Palmitate-Induced Suppression of IGF binding protein-3 Leads to Liver Inflammation

Feb 6, 2017 8:16:08 AM / by Stacy Matthews Branch, DVM, PhD posted in Inflammation, Macrophages, Monocytes, stem cell research, Basic Research

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Insulin-like growth factors (IGFs) are hormones resembling insulin and are important for normal cell growth and division. IGF-binding proteins (IGFBPs) regulate IGF action leading to changes in their effects in the body. IGF-binding protein-3 (IGFBP-3) is the most abundant of the IGFBPs and is made primarily in kupffer cells (specialized liver macrophages).

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Distinct Gene Expression Profiles Shed Light on Leishmania-Macrophages Interactions

Nov 16, 2016 12:00:34 AM / by Stacy Matthews Branch, DVM, PhD posted in Macrophages, PBMCs, Peripheral blood cells, Stem Cells

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Macrophages are formed from peripheral blood precursors called monocytes. They are the first line of defense against invading disease-causing organisms. Macrophages attack invaders by a process of phagocytosis (engulfment and breakdown of particles). They can also help initiate immune responses by T lymphocytes.

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