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Stem Cell-Like Function of Adult Immune Cells Stimulate Healing

Apr 9, 2018 10:05:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Macrophages, Stem Cells, immune cells

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New research suggests that wound fluid induced macrophage clustering shows improved healing.

Tissue damage is repaired by the proliferation of normal cells, tissue stem cell maturation, and scar formation. However, the inflammation associated with tissue damage or injury promotes cell plasticity as part of the tissue repair process. Fibroblasts that are critical for wound healing are mesenchymal cells that are actually derived from myeloid cells such as macrophages. Macrophages are immune cells that are the first line of defense against pathogens. They are also important in wound healing and inflammatory processes.

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Cancer Treatment That Boosts Macrophage Cancer-Fighting Action

Mar 22, 2017 3:21:32 PM / by Stacy Matthews Branch, DVM, PhD posted in cancer prevention, Cytotoxic T Cells, Macrophages

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Many therapeutic strategies are continuously being investigated to find the means to effectively treat cancer. Immunotherapeutic approaches are emerging as very valuable options for patients with different types of cancer. Many of the approaches involve targeting the adaptive immune system. The adaptive immune system involves targeting specifically identified cells by cytotoxic T cells and represents a specialized attack on invading and pathogenic (disease-causing) cells and molecules.

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Palmitate-Induced Suppression of IGF binding protein-3 Leads to Liver Inflammation

Feb 6, 2017 8:16:08 AM / by Stacy Matthews Branch, DVM, PhD posted in liver inflammation, Macrophages, Monocytes, research, stem cell research

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Insulin-like growth factors (IGFs) are hormones resembling insulin and are important for normal cell growth and division. IGF-binding proteins (IGFBPs) regulate IGF action leading to changes in their effects in the body. IGF-binding protein-3 (IGFBP-3) is the most abundant of the IGFBPs and is made primarily in kupffer cells (specialized liver macrophages).

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Microglia, a Product of Bone Marrow Stem Cells, Tie up Loose Ends of Ruptured Blood Vessels

Jun 13, 2016 1:00:50 PM / by Steffen Porwollik posted in blood vessel, Bone Marrow, bone marrow, bone marrow-derived stem cells, hemorrhagic stroke, Macrophages, research, vascular repair

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Scientists discover and visualize the astonishing capability of microglia, macrophages circulating in the brain, to repair broken blood vessels. This finding may open up new avenues for treatment of hemorrhagic strokes and brain microbleeds associated with dementia and cognitive decline.

Every four minutes, a person dies from a stroke in the US. A staggering 15 million people worldwide suffer from an occurrence of this disease every year. Strokes are thus incredibly common and extremely serious. The majority of these strokes is caused by a disruption of the blood flow to the brain, and therapy approaches using pluripotent stem cells show much promise. However, about 13% of strokes are hemorrhagic in nature, where brain blood vessels rupture and blood flows freely into the brain tissue.

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Tumor-Fighting Macrophages Advance Cancer Immunotherapy

Mar 7, 2016 1:00:17 PM / by Karina Palomares posted in Cancer Immunology, cancer immunotherapy, Cytotoxic T Cells, Macrophages

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Researchers have taken an important step in advancing cancer immunotherapy by successfully altering “repair-type” macrophages into “kill-type” macrophages.

Cancer immunotherapy has become one of the most promising new cancer treatment approaches. Existing immunotherapies seek to recruit cytotoxic T cells to recognize and attack tumors. Use of naturally occurring tumor-reactive T cells has been shown to achieve complete, long-lasting remissions, with sometimes minimal or no side effects. In addition, it has been shown to be particularly effective against some of the deadliest types of cancer, including lung and skin cancers.

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