A form of malaria called cerebral malaria can develop in people with malaria infection. This severe complication often causes comas and death can result in some patients. The brain swells and bleeding in the brain tissue can occur. Though, how malaria infection causes this devastating condition is not fully understood.
iPSC technology helps scientists model liver-stage malaria in a dish
Malaria is a parasitic disease which kills millions of lives worldwide. The life cycle of the parasite revolves between a mosquito vector and a human host. Malaria is transmitted when Anopheles mosquitoes bite a human being and release hundreds of sporozoites into the bloodstream of the host. After entering into the bloodstream, parasites migrate to the liver, where they can either remain dormant or initiate an asexual multiplication cycle to produce thousands of merozoites. The newly formed merozoites attack red blood cells and further initiate the asexual replication cycle. Some of the merozoites differentiate into male and female gametocytes, which are the only parasite form that can be transmitted from humans to the mosquito vector.