Blog | HemaCare

Stunted Chikungunya Virus Production and Altered Immune Response in Peripheral Blood Mononuclear Cells Co-infected with Dengue Virus

Jul 10, 2017 1:06:54 PM / by Stacy Matthews Branch, DVM, PhD posted in Mononuclear Cells, PBMCs

0 Comments

Reports of chikungunya virus are increasing worldwide. The mosquito that transmits this virus (Aedes spp.) also transmits the dengue virus, which is related to increased reports of chikungunya/dengue co-infections. The innate immune system is an important component of the response to chikungunya and dengue infections, and these viruses replicate in immune cells (particularly monocytes). Yet, not much is known regarding the biochemical or molecular dynamics of these co-infections or the effects on those infected.

Read More

ABO-Incompatible Liver Transplantation and Humoral Immune Tolerance

Jun 26, 2017 11:20:50 AM / by Stacy Matthews Branch, DVM, PhD posted in Mononuclear Cells, PBMCs

0 Comments

ABO-incompatible liver transplantation has an elevated risk of humoral (antibody mediated) rejection. The age at transplantation and the level of anti-donor blood group antibodies are risk factors for transplant rejection. There are cases in which there is no humoral response to ABO blood group antigens with incompatible liver transplantation. To determine the possible mechanism of this phenomenon, researchers examined the capability of anti-donor ABO antibody production by peripheral blood mononuclear cells from patients with incompatible liver transplants. 

Read More

Peripheral Blood Mononuclear Cells May Help Deliver Anti-Cancer Drugs to Brain Tumors

May 10, 2017 9:02:18 AM / by Stacy Matthews Branch, DVM, PhD posted in bioresearch, Mononuclear Cells, PBMCs

0 Comments

Glioblastomas are highly malignant brain tumors that can be resistant to conventional treatment. Despite the various therapies available, treatment success is very low. One of the main reasons for poor survival rates is the difficulty in getting anti-cancer drugs through the blood-brain barrier (BBB). Therefore, a means to expose brain tumors to effective concentrations without adverse effects to the patient are needed.

Read More

Effect of Medicinal Cannabinoids on Peripheral Blood Mononuclear Cell Signaling

Mar 30, 2017 9:05:05 AM / by Stacy Matthews Branch, DVM, PhD posted in Mononuclear Cells, PBMCs, Basic Research

0 Comments

There is an ever increasing desire to understand the medicinal properties of marijuana. The components of marijuana are numerous; however, the more widely known class of compounds with medicinal activity are cannabinoids. Scientists continue to search for the mechanisms of these cannabinoids in various diseases including cancer and inflammatory conditions.

Read More

Storage Temperature Affects PBMC Gene Expression and Cell Viability

Feb 15, 2017 8:00:57 AM / by Stacy Matthews Branch, DVM, PhD posted in Mononuclear Cells, PBMCs, Basic Research

0 Comments

Peripheral blood mononuclear cells (PBMCs) are used for many biomedical endeavors including therapeutic efforts, clinical trials, and basic research. In the therapeutic arena, they are valuable tools in the development of immunotherapy approaches. They also serve to support diagnostic medicine when used to identify biomarkers of disease.

Read More

      Subscribe Here!

      Posts by Topic

      see all

      Recent Posts