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Experimental Pancreatic Cancer Treatment Redirects Macrophages

May 9, 2016 1:00:20 PM / by Karina Palomares posted in monocytes, pancreatic cancer, PDAC, research

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New research shows that inflammatory macrophages can be redirected and induced to deplete fibrosis characteristic of pancreatic ductal adenocarcinoma tumors.

Pancreatic ductal adenocarcinoma (PDAC) is the fourth most common cause of cancer death, because of its tendency to cause symptoms only at a late and advanced stage. Despite our advancing knowledge of PDAC, the prognosis remains strikingly poor owing to resistance to standard therapies. The tumor stroma comprises abundant extracellular matrix (ECM) and extensive collagen, which often contribute to formation of a dense fibrosis. In addition, the tumor microenvironment is typically marked by a robust infiltrate of immunosuppressive macrophages. Together, these hallmark characteristics form a major barrier to drug delivery. Thus, strategies targeting this tumor microenvironment are necessary to improve the prognosis of PDAC patients.

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Anti-Diabetes Drug “Suffocates” Pancreatic Cancer Cells

Nov 18, 2015 1:00:07 PM / by Karina Palomares posted in metformin, diabetes, glycolysis, oxidative phosphorylation, pancreatic cancer, research

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New research suggests that metformin treatment could effectively eliminate pancreatic cancer stem cells that rely on oxygen-based metabolism for energy production.

Pancreatic cancer is the fourth most common cause of cancer death, because of its tendency to cause symptoms only at a late and advanced stage. There were 49,000 new cases of the disease in 2015 in the United States; only 7.2% survive beyond 5 years. In most cases, by the time signs and symptoms appear, complete surgical removal is not possible and the cancer has already spread to other organs. Thus, development of strategies for earlier detection and new treatments are necessary to improve the prognosis of pancreatic cancer patients.

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Bacterial-Based Immunotherapy to Kill Pancreatic Cancer Cells

Aug 10, 2015 1:00:43 PM / by Karina Palomares posted in Cancer Immunology, cancer immunotherapy, pancreatic cancer, PDAC, research

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Researchers have developed a novel, bacterial-based immunotherapy that homes to tumors and initiates an effective tumor-killing response.

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Mobilizing T Cells to Fight Pancreatic Cancer with Vaccines

Mar 2, 2015 1:00:15 PM / by Daisy posted in GVAX, cancer immunotherapy, CRS-207, pancreatic cancer, research, vaccine

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Clinical trial results for pancreatic cancer vaccines GVAX and CRS-207 demonstrate an improved outcome for patients, resulting from cancer-fighting T cells.

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