Blog | HemaCare

Engineering Hematopoietic Stem Cells for a One-Two Punch of Cancer Immunotherapy

Mar 26, 2014 6:16:13 AM / by Maria posted in PBCs, Cancer, Cell Therapy, Drug Discovery, HSCs, leukemia, lymphoma, Peripheral blood cells, Stem Cell Therapy, Stem Cells, T Cells, Basic Research, Immunotherapy (Immunology)

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In Part I of this series we introduced T cell based immunotherapy and in Part II we discussed how chimeric antigen receptors (CARs) expressing T cells can be even more potent. In Part III below, we expand this concept further by covering hematopoetic stem cells and additional ways they can be engineered for promising immunotherapy of cancer and leukemia.

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Will T Cells Be the Future Basis of Cancer Therapy?

Mar 12, 2014 6:00:07 AM / by Maria posted in PBCs, antibodies, Bone Marrow, Cancer, Cell Therapy, Cord Blood, Drug Discovery, PBMCs, Peripheral blood cells, Stem Cell Therapy, Stem Cells, T Cells, T lymphocytes, Tumors, Basic Research, Immunotherapy (Immunology)

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Recent data suggest that the average person has about a 40% chance of developing cancer at some point in his or her lifetime. [1] If those statistics are not frightening enough, let’s talk treatment: chemotherapy, radiation, surgery, chemical-based drug therapy, or a combination of the above. And don’t forget the various side effects of cancer therapy, many of which are a result of the destruction of crucial adult stem cells in the body. Because of this, stem cell transplants have been performed with fresh stem cells originating from bone marrow, peripheral blood, or cord blood to help replenish a patient’s hematopoietic system.

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Drug Screening in Healthy and Diseased PBMCs

Jan 22, 2014 2:32:37 PM / by Maria posted in drug screening, PBCs, proliferation, apoptosis, Drug Discovery, infection, Inflammation, migration, PBMCs, Peripheral blood cells, viability, Basic Research

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Peripheral Blood Mononuclear Cells (PBMCs) can be used in drug screening.  In Part I from this series, we discussed how they can be used to assay drug activity including effects on proliferation, viability, apoptosis, inflammation, and migration in healthy and disease cell models.  There are related assays available to measure the effects of drug treatment and, especially for researchers that prefer to use human samples, peripheral blood mononuclear cells are often the cells of choice (PBMCs) are often the cells of choice.  The advantages of using human cells initially are immense.

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Improved Vectors For Reprogramming Peripheral Blood Cells

Dec 31, 2013 2:00:16 AM / by Maria posted in PBCs, cellular reprogramming, iPSCs, Peripheral blood cells, Stem Cells, Uncategorized, Basic Research

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Reprogramming peripheral blood cells is performed via introduction of key factors by viral vectors.  New vectors make this process safer for use in humans.  

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Key Factors For Reprogramming Peripheral Blood Cells

Dec 26, 2013 9:21:39 AM / by Maria posted in PBCs, cellular reprogramming, iPSCs, Peripheral blood cells, Stem Cells, Basic Research

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Cellular reprogramming of peripheral blood cells is opening the door to new scientific advances.  In Part I of this series, we discussed why peripheral blood cells are a prime source for cells to use for iPSC induction.  Here we discuss the critical factors responsible for cellular reprogramming of peripheral blood cells.   

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