Blog | HemaCare

A study using peripheral blood mononuclear cells (PBMCs) demonstrates the link between women’s stress levels and shortened telomere length.

Stress is one of the body’s major means of reacting to life challenges, dangers, and difficulties. Various chemicals are released in the body that promote cellular and organ-level changes needed to cope with, adjust, and respond to stressors. The effects that are felt with chronic stress range anywhere from pain, digestive problems, and fatigue to sexual, cognitive, immunological, and emotional effects. Women are particularly vulnerable to the effects of stress due to unique challenges they face, including gender and race-based discrimination and forms of victimization.

Scientists examined the peripheral blood mononuclear cell (PBMC) profiles of patients with and without psoriasis, including those that both responded to classic treatments and didn’t respond. They then analyzed the profile of those immune cell types. Here are the results of that study.

There are often differences among patient populations for a given disease in how effective a treatment provides medical relief. An important part of personalized medicine is identifying patients that are not likely to respond to a treatment regimen for a specific disease or condition. Doing this can limit the loss of time and resources in using ineffective treatments and can allow the use of personalized treatments in these populations.

Researchers believe combining elotuzumab and PBMC treatments with ASCT and lenalidomide maintenance may be an effective treatment option for multiple myeloma.

Multiple myeloma (MM) is a hematological cancer of bone marrow plasma cells. In MM, the antibody-producing plasma cells transform into malignant myeloma cells that produce abnormal antibodies (M proteins). When M proteins accumulate, they outnumber and overcrowd the normal antibodies. Patients with MM can experience bone and kidney damage, anemia, and an impaired immune system.

New research using PBMCs has uncovered the role of cellular energy pathways in chronic fatigue syndrome.

Chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis, but recently referred to as systemic exercise intolerance disease, is a debilitating disease without a known cause. Historically, it has been thought of as a manifestation of a psychological condition. Some references still speculate that psychological stress may be a trigger, as well as viral infection or hormone imbalances. Whatever the cause, CFS is characterized by extreme fatigue that cannot be explained by an obvious medical condition. It is worse after physical or mental activity, yet it is not relieved by resting.

Charles River’s Humanized Mouse Model Accelerates Research by Incorporating HemaCare PBMCs

Last week, FierceBiotech featured the new mouse “humanization” kit from Charles River that will incorporate pre-selected human peripheral blood mononuclear cells (PBMCs) from HemaCare. ^[1] So-called “humanized” mice are genetically engineered so that they lack significant components of their immune system. These immunodeficient mice are carefully engrafted with human PBMCs, allowing them to develop human immune cells, thereby replicating an environment that more closely resembles a human immune system.  The mice are commonly used to model the human immune response to various cancer treatments (including cell and gene therapy), as well as treatments for disease states related to the immune system.