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Lung Cancer Patients Live Longer with Drug Targeting T cells

Feb 24, 2016 1:00:46 PM / by Daisy posted in Cancer Immunology, clinical trial, PD-1, PD-L1, pembrolizumab


Pembrolizumab, a newer drug, harnesses T cells to tackle cancer. For certain lung cancer patients, this means having twice the lifespan than that accorded by chemotherapy! 

For patients battling lung cancer, the majority are of the non-small-cell lung carcinoma (NSCLC) subtype. Among these, a subgroup of tumors produce a protein, PD-L1, which enables escape from attack by the patient’s immune system (see here). Specifically, PD-L1 binds to PD-1 receptors on T cells, thereby preventing T cells from activating, proliferating, and/or producing cytokines, so that T cells do not mount an attack towards the PD-L1-positive tumor cells.

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Targeting T Cells: Clinical Trial Results for Metastatic Bladder Cancer

Jan 26, 2015 1:00:12 PM / by Daisy posted in Cancer, cancer immunotherapy, clinical trial, PD-L1, PD1, Basic Research


Cancer cells evolve to escape our immune surveillance. Newer technologies employ therapeutic regimens that target T cells to wake up the sleeping giant.

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