Visceral or central obesity is characterized by an excess of abdominal fat, and is correlated with risk of cardiovascular disease and other health conditions such as type 2 diabetes and dyslipidemia. Central obesity is measured by the waist circumference and is considered to be a stronger predictor of death risk than body mass index. Increases in blood cytokine and chemokine levels are associated with central obesity and is an indication that chronic inflammation is associated with the condition.
Macrophages are formed from peripheral blood precursors called monocytes. They are the first line of defense against invading disease-causing organisms. Macrophages attack invaders by a process of phagocytosis (engulfment and breakdown of particles). They can also help initiate immune responses by T lymphocytes.
Peripheral blood mononuclear cells (PBMCs) are peripheral blood cells containing a round nucleus. Examples of these types of cells include the various types of lymphocytes (including T cells) and monocytes. These are different from other blood cells that contain multi-lobed nuclei (e.g., neutrophils and eosinophils) and those that have no nucleus such as platelets and red blood cells (erythrocytes).
Several omics data such as genomics and transcriptomics, have been available for several tissues, including the blood. Now, for the first time we have access to the proteome of human blood.