In Alzheimer's disease, brain cells die, and their connections to one another degenerate leading to decline in mental function. The brain changes that occur in Alzheimer's disease are associated with the production and deposition of beta-amyloid plaques. Currently, treatment of Alzheimer's disease focuses on delaying or slowing mental decline and addressing behavioral complications. There are a few U.S. FDA−approved drugs used to treat Alzheimer's disease symptoms. These drugs regulate neurotransmitters, but have limited duration, only work in some patients, and do not address the underlying cause.
Regrowth and healing of skin after severe traumas such as burns and other extensive skin damage are significant medical challenges and depend on complex skin regeneration mechanisms. Skin and other tissue regeneration processes start with platelet degranulation and clotting that are associated with the release of a number of factors including clotting factors and cytokines. Skin tissue regeneration also relies on the action of growth factors. Platelet-rich plasma (PRP) is beneficial for tissue regeneration processes because platelets promote the secretion of growth factors that are essential in wound healing.
Leukapheresis is a procedure to separate white bloods cells (including dendritic and progenitor cells) from a blood sample. Products obtained from leukapharesis procedures, leukopaks, are regularly used in the research setting. They are also used for cell therapy process development and clinically for certain treatment procedures for blood disorders. Another way to obtain white blood cells and platelets is to obtain them from the buffy coat.
Lipotransfers are ideal for restorative surgery, but retention is a problem. HemaCare provided the platelets for a study examining just how platelet-rich plasma helps make the fat stick around.
In this age of crash diets and liposuction, it might sound surprising that some people receive fat transplants. But seriously, fat grafting is widely used and valued as a feasible method for addressing moderate defects caused by injuries, surgical removal of tumors, and congenital deficiencies. Fat grafting is safe and has the look and feel of normal soft tissue. However, long-term volume retention is suboptimal (30-70%), often requiring multiple surgeries.
Experiments show that blood plasma from the young reverse age-associated cognitive declines. What ingredient make it possible?
It sounds like something out of a science fiction movie, or the mind of a researcher gone off the rails. But a series of intriguing discoveries hint that young blood may help treat problems associated with the elderly.