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Study Looks at MSCs for Wound Healing in Diabetic Rats

Aug 18, 2020 10:05:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Regenerative Medicine, Stem Cells

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Researchers from the Third Xiangya Hospital of Central South University, Changsha, China found overexpressing c-Jun promoted accelerated wound healing.

The high levels of blood glucose common in people and animals with diabetes can lead to peripheral vascular disease, peripheral neuropathy, and an impaired immune response. The resultant decreased blood flow and lower immune cell migration to a wound impede the normal healing process. Medical approaches to consistently or reliably improve slow or nonhealing wounds is lacking. However, the use of mesenchymal stem cells (MSCs) is being studied as an intervention to promote better cutaneous wound healing. MSCs are crucial for regenerative wound healing because they have the capacity to enhance cellular differentiation, immune-modulation, and release of growth factors needed for angiogenesis and re-epithelialization, thus promoting healthy granulation tissue formation.

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PBMC Reprogramming Opens Doors in Regenerative Medicine

Aug 6, 2019 10:04:00 AM / by Nancy Andon, MSc posted in PBMCs, Regenerative Medicine, Stem Cells

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New clinical applications in regenerative medicine are motivating an intense interest in easily accessible sources for producing human stem cells. The 2007 breakthrough showing that induced pluripotent stem cells (iPSC) could be generated directly from adult cells has been a boon to the industry. Since that time, there has been a steady refinement of the cell culture techniques that guide the cell reprogramming process.

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A New Player in Tissue Bioengineering: Vesicles from Stem Cells Can Regenerate Bone.

Apr 4, 2016 1:00:19 PM / by Dalia Gaddis posted in Bone Marrow, Regenerative Medicine, Stem Cells, Basic Research

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Researchers find that extracellular vesicles derived from bone marrow stem cells can lead to osteoblast activation and bone regeneration.

While the idea of regenerating organs such as hearts, lungs and kidneys in the laboratory is still purely experimental and a long way from being used for treatment procedures in patients, everyday scientists are inching closer to that dream. This time, the success is with bone tissue re-engineering, as scientists discover that extracellular vesicles from bone marrow stem cells can regulate osteoblast activity and lead to bone regeneration.

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Stem Cells Have Smart Switch to Keep Their Number Under Control

Feb 15, 2016 1:00:19 PM / by Shweta posted in Regenerative Medicine, Stem Cell Therapy, Stem Cells

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The Prkci gene maintains the stem cells homeostasis in the adult body

One of the striking features of stem cells is their ability to make copies of themselves whenever it is required, a property known as 'self-renewal'. This process keeps cell division under control, which is required for continuous regeneration in the human body. It is very important to keep proliferation under check; otherwise, an excess of symmetric division can lead to teratoma formation, but also an insufficient number may inhibit the repair and maintenance of the body. In a nutshell, stem cells play a very crucial role in maintaining the homeostasis of the adult body.

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Embryonic Stem Cells Go to Space!

Jan 13, 2016 1:00:32 PM / by Karina Palomares posted in Regenerative Medicine, Stem Cells

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A study performed on the NASA space shuttle Discovery showed that microgravity inhibits the regenerative potential of embryonic stem cells.

Since the discovery of stem cells, NASA researchers have been interested in how they are influenced by space travel. Exposure to microgravity often causes the breakdown of tissue and function, which poses serious challenges to the health of astronauts in space. Astronauts experience muscle atrophy, bone density loss, and slower heart rates in orbit. Affected tissues often rely on tissue-specific stem cells for regeneration and repair. Thus, studies examining the maintenance of tissue regenerative health during spaceflight are critical.

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