Researchers from the Third Xiangya Hospital of Central South University, Changsha, China found overexpressing c-Jun promoted accelerated wound healing.
The high levels of blood glucose common in people and animals with diabetes can lead to peripheral vascular disease, peripheral neuropathy, and an impaired immune response. The resultant decreased blood flow and lower immune cell migration to a wound impede the normal healing process. Medical approaches to consistently or reliably improve slow or nonhealing wounds is lacking. However, the use of mesenchymal stem cells (MSCs) is being studied as an intervention to promote better cutaneous wound healing. MSCs are crucial for regenerative wound healing because they have the capacity to enhance cellular differentiation, immune-modulation, and release of growth factors needed for angiogenesis and re-epithelialization, thus promoting healthy granulation tissue formation.