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Scientists Engineer Diaphragm in the Lab using Stem Cells

Jan 8, 2016 1:00:01 PM / by Shweta posted in Cell Therapy, Regenerative Medicine, Stem Cell Therapy, Stem Cells, tissue engineering, Basic Research


Stem cells were instrumental in creating new functional diaphragm

The diaphragm is a one of the vital organs of the body; it is responsible for several important functions including its very critical role in respiration. During the process of breathing, the diaphragm contracts to add volume to the thoracic cavity, which enables the lungs to make room for more air. It also separates the thoracic and abdominal cavities. The malfunction of the diaphragm can lead to several life threatening conditions, which can be acquired or congenital. Congenital diaphragmatic hernias (CDH) are one of the most common birth defects (1:2500) caused by a malformation, or hole, in the diaphragm.

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Stem Cells and Gene Editing Technology Together Create a Mini-Kidney in the Lab

Nov 30, 2015 1:00:54 PM / by Shweta posted in disease-state cells, iPSCs, Regenerative Medicine, Stem Cells


Gene editing technology along with stem cells helped scientists develop a miniature scale kidney

In the past, researchers already developed complex kidney structures using stem cells. Now, the main aim of kidney tissue engineering is to develop new therapies to repair kidney damage and thus reduce the need for dialysis and transplantation. Recently, scientists at University of Washington in collaboration with Brigham and Women's Hospital and Harvard Stem Cell Institute (HSCI) have grown mini-kidneys in the laboratory [1]. The ex-vivo kidney could be used to study abnormalities in kidney development, chronic kidney disease, and the effects of toxic drugs on acute and chronic kidney conditions.

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Stem Cell Quandry: Which Precursor is Best for Ailing Hearts?

Nov 23, 2015 1:00:13 PM / by Shweta posted in Cardiovascular Disease, Cell Therapy, Regenerative Medicine, Stem Cell Therapy, Stem Cells, Basic Research


Researchers study alternatives to bone marrow-derived stem cells for post-heart attack tissue repair

Stem cell-based therapy is emerging as a promising modality to rejuvenate a dying heart after heart failure, a leading cause of morbidity and mortality worldwide. Largely, clinical trials have used bone marrow-derived stem cells to improve the cardiac performance in ailing hearts. Unfortunately, bone marrow-derived stem cells could not help patients with this devastating disease except for very minor temporary improvements, which generally go away with the time.

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Making Kidneys from Stem Cells -- and Making Them Work

Oct 12, 2015 1:00:07 PM / by Maria posted in iPSCs, Regenerative Medicine, Stem Cells, Basic Research


Building a kidney with stem cells is not enough -- it has to function as well. Scientists move closer to that goal.

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New Stem Cell Discovery with iPSCs May Help to Diminish Graft Rejection

Sep 7, 2015 1:00:17 PM / by Shweta posted in Cell Therapy, cellular reprogramming, iPSCs, Regenerative Medicine, Stem Cell Therapy, Stem Cells, Basic Research


Scientists used humanized mice to demonstrate the differential immunogenicity of cells derived from autologous induced pluripotent stem cells (iPSCs)

The discovery of induced pluripotent stem cells (iPSCs) has been considered as one of the groundbreaking findings in the history of life science research. This innovation has changed the direction of stem cell research around the world and may represent an ideal cell source for future regenerative therapies. But the fact that iPSCs are derived from an individual’s own body does not eliminate the possibility of immune rejection completely. A research group at UC San Diego previously reported that abnormal gene expression may elicit the immune system to reject certain cells derived from iPSCs.

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