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Developing Antibody Drugs Against B-cells

Jan 11, 2016 1:00:44 PM / by Daisy posted in Cancer Immunology, chronic lymphocytic leukemia, clinical trial, CLL, obinutuzumab, research, rituximab

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The success of rituximab as an antibody drug targeting B-cells has led to the development of obinutuzumab – a similar, third-generation drug

Chronic lymphocytic leukemia (CLL) is a B-cell disease that is currently incurable. Combining targeted drugs has improved overall survival. However, not all patients benefit, because B-cells can harness any of several mechanisms to gain unrestricted proliferative capacity (see here).

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Using Dendritic Cells to Arm the Immune System via Dying Cancer Cells

Mar 16, 2015 1:00:25 PM / by Daisy posted in B Cells, follicular lymphoma, cancer immunotherapy, clinical trial, research, rituximab

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Scientists are exploring localized treatment in follicular lymphoma (FL) using dendritic cells that could have long-range benefits on all FL lesions.

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