It doesn’t get much trendier these days than either 3-dimentional (3D) or stem cells. Put the two together and you have cooler-than-cool 3D stem cell models, a topic pregnant with possibilities.
We discuss here the mechanism by which dendritic cells mistake human or self-DNA for pathogenic DNA. When self-DNA fragments form aggregates with LL37, it results in psoriasis.
The skin is a specialized lymphoid organ, called “SALT” or “skin-associated-lymphoid-tissue”. There are 1 million T cells per square inch of skin and their dysfunction can result in disease.