Researchers find that self-reactive IgE can worsen autoimmune inflammation in systemic lupus erythematosus patients.
Systemic lupus erythematosus (SLE), or as commonly known as lupus, is a chronic autoimmune disease that affects multiple organs in the body. In this disease, the immune system generates self-reactive immune cells and antibodies against the body’s nucleic acids. Lupus symptoms vary dramatically from one patient to another but usually include fever, pain, fatigue, abutterfly shaped rash on the cheeks and nose and skin lesions. Lupus can cause serious damage to major organs such as the kidneys, lungs and heart. Currently, there is no cure, only treatments to keep symptoms under control. Treatment usually includes non-steroidal anti-inflammatory drugs, corticosteroids or immunosuppressive therapy.1