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Can Stem Cells Treat Lyme Disease?

Sep 10, 2018 10:12:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Stem Cell Therapy, Stem Cells, Infectious Disease

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Because many people with Lyme disease do not fully recover with antibiotics alone, many are seeking stem cell treatments as an option.

Lyme disease is transmitted by the bite of blacklegged ticks (deer tick, Ixodes scapularis) infected with Borrelia burgdorferi bacteria. A number of debilitating and long-lasting symptoms can include the development of a distinctive skin rash (erythema migrans), fever, fatigue, muscle pain, and headaches. Due to the nonspecific and diverse symptoms, Lyme disease is often misdiagnosed and can progress to serious conditions of the heart, nervous, and musculoskeletal systems.

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Therapeutic Gene Editing in CD34+ Stem Cells from Patients with Fanconi Anemia

Nov 8, 2017 3:38:25 PM / by Stacy Matthews Branch, DVM, PhD posted in Stem Cell Therapy, Stem Cells

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Gene (or genome) editing refers to various technologies that are used to alter genetic material. This technology is used as a new means to treat diseases including genetic disorders. Fanconi anemia is an inherited disease that affects bone marrow leading to decreased production of all blood cell types. In general, editing of CD34+ (hematopoietic) stem cells have proven more difficult than for fibroblasts or embryonic stem cells. Some advances have been achieved in this regard; however, the efficiency of gene editing for CD34+ stem cells remains less than that possible with lentiviral vectors.

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Use of Cord Blood CD34+ Stem Cells for Large-Scale Production of Human Neutrophils

Aug 24, 2017 3:12:38 PM / by Stacy Matthews Branch, DVM, PhD posted in Neutrophils, stem cell research, Stem Cell Therapy, Stem Cells

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Severe and prolonged neutropenia is a common consequence of cancer chemotherapy and is associated with an increased risk of severe infections. Transfusion of donor neutrophils is a viable option to combat this, but obtaining matched donors is a dilemma. There are pharmacologic interventions aimed at shortening the duration of neutropenia and combatting infection; however, infection risk remains high due to a lack of response to these treatments in many patients.

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CD34 Stem Cell−Derived Natural Killer Cells Are Better for Immunotherapy than Peripheral or Cord Blood Natural Killer Cells

May 19, 2017 2:21:35 PM / by Stacy Matthews Branch, DVM, PhD posted in bioresearch, new immunotherapy advances, Stem Cell Therapy, Stem Cells, Basic Research

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Natural killer (NK) cells are immune cells that can be used as a form of immunotherapy and are particularly effective in the treatment of acute myeloid leukemia (AML). NK cells can be obtained from peripheral or cord blood, but with low yields. This limits their use for patients that need multiple treatments. They also have a short survival time and do not proliferate or remain viable after injection into patients. The availability of NK cells for therapy can be enhanced by stimulating their production from hematopoietic (CD 34+) stem cells.

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Improvement in Diastolic Function After CD34+ Cell Transplantation in Patients with Nonischemic Dilated Cardiomyopathy

Apr 13, 2017 9:42:42 AM / by Stacy Matthews Branch, DVM, PhD posted in biomedical research, stem cell research, Stem Cell Therapy, Stem Cells, Basic Research

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Dilated cardiomyopathy occurs when the heart muscle stretches and becomes weakened, leading to less efficient pumping of the blood throughout the body. It is the most common form of non-ischemic cardiomyopathy (not due to coronary artery disease). Dilated cardiomyopathy may be associated with damage to the heart muscle from a variety of causes such as inflammation, infections, and toxic substances. Diastolic dysfunction seen in patients with dilated cardiomyopathy refers to insufficient relaxation and filling of the ventricles during the second part of the heart-pumping phase (leading to increased pressure in the ventricles).

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