Blog | HemaCare

Study Looks at MSCs for Wound Healing in Diabetic Rats

Aug 18, 2020 10:05:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Regenerative Medicine, Stem Cells

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Researchers from the Third Xiangya Hospital of Central South University, Changsha, China found overexpressing c-Jun promoted accelerated wound healing.

The high levels of blood glucose common in people and animals with diabetes can lead to peripheral vascular disease, peripheral neuropathy, and an impaired immune response. The resultant decreased blood flow and lower immune cell migration to a wound impede the normal healing process. Medical approaches to consistently or reliably improve slow or nonhealing wounds is lacking. However, the use of mesenchymal stem cells (MSCs) is being studied as an intervention to promote better cutaneous wound healing. MSCs are crucial for regenerative wound healing because they have the capacity to enhance cellular differentiation, immune-modulation, and release of growth factors needed for angiogenesis and re-epithelialization, thus promoting healthy granulation tissue formation.

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Studies Look at Mesenchymal Stem Cells for Treating Preeclampsia

Jul 14, 2020 10:06:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Cell Therapy, Stem Cells

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Recent studies suggest that mesenchymal stem cells (MSC) of the maternal decidua may prove to be an effective treatment for patients suffering from preeclampsia.

Preeclampsia is one of the most common causes of maternal and perinatal morbidity and mortality, affecting as high as 8% of pregnant women worldwide. It is a severe cardiovascular disorder that develops after 20 weeks of pregnancy and is characterized by a sudden onset of hypertension, swelling of the limbs and face, proteinuria, and adverse effects on various organs, including the kidneys and liver. If left untreated, maternal organ damage can occur, and the fetus can be deprived of sufficient blood flow and oxygen. Eclampsia (seizures) and HELLP syndrome (hemolysis, elevated liver enzymes, low platelet count) may also ensue. 

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Could Mesenchymal Stem Cells Treat Patients Severely Ill from COVID-19?

Jun 9, 2020 10:05:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Bone Marrow, Stem Cells

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Clinical trials all over the world are showing positive results when treating COVID-19 patients suffering from ARDS with MSCs.

The worldwide race to develop effective therapies for complications from COVID-19 infection are ongoing. Patients with particularly severe responses are often diagnosed with acute respiratory distress syndrome (ARDS).

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Treatment with Mesoblast’s Remestemcel-L Leads to an 83% Survival Rate in Patients with ARDS

Jun 2, 2020 10:03:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Stem Cells

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COVID-19 patients dependent on ventilators showed promising results when treated with new drug in New York’s Mt. Sinai hospital.

The U.S Food and Drug Administration approved Mesoblast’s Investigational New Drug (IND) application to treat patients with COVID-19−related Acute Respiratory Distress Syndrome (ARDS) using remestemcel-L, an intravenous (IV) infusion of allogeneic mesenchymal stem cells (MSCs).

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Could Stem Cell Therapy Be the Better Treatment for MS?

May 12, 2020 10:08:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Autoimmune Disorders, Stem Cell Therapy, Stem Cells

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A Phase III clinical trial comparing hematopoietic stem cell transplants to immunomodulators is underway.

Multiple sclerosis (MS) is an autoimmune disease characterized by the destruction of the myelin sheath of nerve fibers. There is no cure for the condition, but there are a number of FDA-approved immunomodulators or disease-modifying therapies to reduce relapses and slow disease progression. Despite the availability of these drugs, their varying efficacy, adverse effects, and expense are significant concerns. Therefore, a means to safely and effectively control MS symptoms and progression is still under investigation.

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