Blog | HemaCare

Extracellular Vesicles Boost Grafting Ability in Cells

Aug 20, 2019 10:11:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Bone Marrow, Stem Cells, Blood Disorders

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A new study shows that we may be able to boost the grafting ability in cells for people receiving a bone marrow transplant.

Allogenic stem cell transplantation is a treatment approach in people with diseases that are destructive to the bone marrow, such as multiple myeloma, leukemia, and Hodgkin´s lymphoma. The goal is to restore bone marrow after total-body chemotherapy and irradiation. The transplantation procedure involves transferring hematopoietic stem cells from compatible, healthy donors to a patient. An important complication of this procedure is rejection and destruction of the donated stem cells by the recipient’s immune system before engraftment can occur.

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PBMC Reprogramming Opens Doors in Regenerative Medicine

Aug 6, 2019 10:04:00 AM / by Nancy Andon, MSc posted in PBMCs, Regenerative Medicine, Stem Cells

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New clinical applications in regenerative medicine are motivating an intense interest in easily accessible sources for producing human stem cells. The 2007 breakthrough showing that induced pluripotent stem cells (iPSC) could be generated directly from adult cells has been a boon to the industry. Since that time, there has been a steady refinement of the cell culture techniques that guide the cell reprogramming process.

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Mobilization Mechanics: The Complex World of Stem Cell Mobilization

Jul 24, 2019 10:11:00 AM / by Nancy Andon, MSc posted in Apheresis, Stem Cells

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Stem cells are the foundation from which all other cells with specialized functions are generated. Stem cells are primarily found in the bone marrow, where they are produced, but can be induced to migrate into the peripheral blood circulation through a process known as mobilization.

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HemaCare Aids Strategy for Boosting Gene Therapy Efficiency

May 21, 2019 10:06:00 AM / by Nancy Andon, MSc posted in Gene Therapy, bone marrow stem cells, CD34, Stem Cells, mobilized peripheral blood

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An independent publication cites the use of bone marrow and mobilized peripheral blood sourced from HemaCare in a study aimed at improving the efficiency of resource consumption in gene therapy.

The publication, published in the journal Molecular Therapy, focuses on the use of lentiviral vector (LV) to introduce corrected versions of defective genes into stem cells. The goal of gene therapy is to transplant these stem cells into people suffering from genetic disease, in hopes of restoring the function of the faulty gene. One of the main challenges in this clinical strategy is the cost; substantial amounts of LV are needed to modify a therapeutically effective dose of stem cells.

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Stem Cells Working on Matters of the Heart

Apr 9, 2019 10:06:00 AM / by Stacy Matthews Branch, DVM, PhD posted in cd 34 stem cells, heart attacks, heart disease, Stem Cells

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After suffering from a heart attack, patients may eventually have a treatment option which uses their own stem cells to repair and restore heart muscle tissue.

According to the Centers for Disease control, over 600,000 people in the U.S. die yearly from heart disease, and 735,000 Americans have a heart attack each year. Acute myocardial infarction (heart attack) occurs when blood flow to the heart muscle is blocked leading to damage to the heart muscle tissue.  The heart tries to heal after an infarction, but this involves the formation of scar tissue that does not restore adequate function to the heart. The advancement of regenerative medicine using adult stem cells for cardiac tissue repair has the potential to provide a means to repair heart tissue in a way that returns full heart muscle cell function.

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