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Stem-like CD8 T Cell Reservoir Plays Critical Role in Protecting and Sustaining Anti-tumor T-Cells

Jul 6, 2021 10:10:00 AM / by Stacy Matthews Branch, DVM, PhD posted in T Cells, Tumors

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Yale scientists have investigated how a subset of specific T cells survive a microenvironment within a tumor throughout the progression of the cancer.

 Precursor stem-like CD8+ T cells help to sustain anti-tumor T cell responses and promote effective immunotherapy treatment response. Although tumor cell signals cause T cells to differentiate, making them ineffective against tumors, a population of the stem-like T cells is maintained.

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Ocrevus Lessens Pro-Inflammatory T-Cells in PPMS

Jun 15, 2021 10:15:00 AM / by Stacy Matthews Branch, DVM, PhD posted in B Cells, Autoimmune Disorders, Inflammation, T Cells

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Ocrevus’s main immune cell target is B-cells, but a small study has shown that it can also lessen pro-inflammatory immune T-cells in patients with primary progressive multiple sclerosis.

Multiple Sclerosis (MS) is a chronic inflammatory, neurodegenerative, and demyelinating autoimmune disorder. The primary progressive form (PPMS) is characterized by a worsening of neurologic function with a gradual accumulation of disability from the onset of disease. The limited understanding of the pathogenesis of PPMS has hindered the development of reliable and effective treatments. However, there is an approved intravenous therapy, Ocrevus (ocrelizumab), a humanized monoclonal antibody developed by Genentech for treating patients with PPMS.

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New Research Shows the Vital Role Metabolic Signaling Plays in Regulating Specialized T Cells

Jun 1, 2021 10:15:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Autoimmune Disorders, Cancer, T Cells

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Scientists at St. Jude Children’s Research Hospital revealed that metabolic signaling mechanisms regulate the function of an eTreg cell.

Foxp3-expressing regulatory T cells are critical components of the immune system for the regulation of immune responses and the suppression of other immune cells for the maintenance of self-tolerance and regulation of immunity against pathogens and tumor cells.

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Modification of STAT3 Expression by HIV-1 Proviral Integration May Encourage Ex Vivo T-Cell Overgrowth

May 25, 2021 10:30:00 AM / by Stacy Matthews Branch, DVM, PhD posted in T Cells

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A new study out of Tufts University suggests new experimental systems may be useful in studying how HIV integration can affect normal cells' growth properties in vivo.

The persistence of HIV-1 in CD4 T cells during antiretroviral therapy is thought to be associated with T cells that contain a transcriptionally silent form of the virus that is not affected by antiretroviral drugs. Studies have shown that proviral integration in the human genome has led to the development of lymphomas in patients with AIDS. Integrated HIV-1 proviruses may activate cellular gene expression, can replicate with the host cell, and can be transmitted from one cell generation to the next.

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SARS-CoV-2 Variants are Being Recognized by T Cells

May 18, 2021 10:05:00 AM / by Stacy Matthews Branch, DVM, PhD posted in T Cells, Vaccine Research

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The COVID-19 vaccine uses T cells to recognize the virus, and researchers have found that the CD8+ T cells still recognize the different variants of the virus.

In the United States and abroad, there are reports of the emergence of mutations in SARS-CoV-2 (the virus that causes COVID-19) in human populations. This phenomenon raises concerns regarding whether there is any protection provided by immunity developed to the first virus.

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