Researchers have discovered that the use of antibody blocks TREM2 proteins can empower immune cells and destroy tumors, and eliminate completely in mouse models when they were combined with anti-PD-1 immunotherapy.
Anti-cancer immunotherapy uses the body’s immune system to destroy tumor cells. Despite breakthroughs in this medical arena, a limited number of patients actually benefit from these therapies. A significant reason for the less-than-desirable responses is tumor cells’ ability to circumvent various T-cell immune mechanisms. Therefore, populations of resistant tumor cells hinder the effectiveness of current immunotherapeutic approaches in many patients.