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Tumor-Adjacent Dendritic Cells Crucial for Cancer Growth in T-Cell Leukemia

Jul 13, 2016 1:00:11 PM / by Steffen Porwollik posted in ALL, leukemia, research, stromal cells, T Cells, T lymphocytes, tumor microenvironment, white blood cells

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Scientists examine the effect of the tumor microenvironment on cancer fate in acute lymphocytic leukemia (ALL), a disease prevalent in young children. They find that the tumor-adjacent dendritic cells provide essential cues for cancer growth.

For the past fifty years, the incidence of acute lymphocytic leukemia (ALL), a cancer of immature white blood cells, has been rising steadily. Currently, about 6,500 new cases occur annually in the US. The onset of the wretched disease is most common in early childhood, between ages 2 and 5, but can also happen later in life. Luckily, modern chemotherapy and stem cell approaches have resulted in a substantial increase in the 5-year survival rate for children affected by the disease, to over 75%. However, outlook remains poor for those that do not respond well to these therapies. As is the case for the disease’s chronic counterpart, CLL, more treatment options are sorely needed (as we recently reported).

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Nipping HIV Transfer from Monocyte Derived Dendritic Cells in the Bud

Jul 4, 2016 1:00:15 PM / by Steffen Porwollik posted in actin, dendrites, HIV, macropinocytosis, research, shRNA, T Cells, Helper T Cells, T lymphocytes

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During HIV infection, the virus is taken up by dendritic cell populations (modeled in vitro by monocyte derived dendritic cells, MDDC), which subsequently transfer the virus to T lymphocytes. Scientists identified MDDC processes that affect transfer success – revealing ways to prevent early virus dissemination.

Dendritic cells are the human body’s border patrol. Many of these cells circulate in body areas that are in contact with the outer world, such as the linings of the stomach and nose or in the skin. When they encounter a foreign (and possibly dangerous) object, they swiftly scoop it up and present its characteristics to the authorities, the cell-mediated immune system in the form of T cells. Once the T cells have received the invader's footprint, they spring into action by replicating and secreting cytokines that shape the body’s immune response, eventually neutralizing the intruder.

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Epigenetic Therapy May be a Boon for Aggressive Leukemia

Aug 24, 2015 1:00:27 PM / by Shweta posted in Cancer, Cancer Immunology, cancer immunotherapy, clinical trials, Innovation, leukemia, research, T lymphocytes, white blood cells

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New discovery can make an existing leukemia treatment more effective

Prolymphocytic leukemia (PLL) is a rare and aggressive form of malignancy characterized by marked lymphocytosis and splenomegaly. PLL represents only 2% of all chronic lymphoid leukemias in adults over the age of 30. Most patients with PLL shows involvement of the peripheral blood, bone marrow, lymph nodes, liver, and spleen. In addition, skin infiltration and serious effusions may also occur at rates of approximately 25 and 15 percent, respectively.

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Stem Cell Test to Determine Cytokine Release Syndrome Ahead of Time

Jun 22, 2015 1:00:31 PM / by Shweta posted in drug screening, Innovation, PBMC, research, Stem Cells, T lymphocytes, white blood cells, Whole Blood

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Another potential application of human stem cells is to recognize side effects of drugs

Biological therapy is a form of treatment that uses biological materials such as antibodies and stem cells. Several biological therapies, including monoclonal antibodies, are now well established as part of the treatment for many diseases such as cancer, transplant rejection, autoimmune disorders, and infections. Personalized medicine is now a key emerging technology in drug development. However, they can cause adverse side effects in humans. Therefore, biologic therapies require the use of human tissue-based bioassays to measures the efficacy and safety of the drug.

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Tregs opens up Exciting Opportunities for Cell Based Therapies

Sep 22, 2014 1:00:40 PM / by Shweta posted in GMP, GVHD, leukapheresis, Cell Therapy, cGMP, clinical grade compliance, Innovation, research, T lymphocytes, white blood cells, Whole Blood

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Manufacturing of clinical grade Tregs for cell based therapies

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