Blog | HemaCare

CAR-Expressing T Cells: Driving the Express Track to Cancer Immunity

Mar 19, 2014 6:10:31 AM / by Maria posted in cancer, Cancer Immunology, cancer immunotherapy, cell therapy, chemotherapy, drug development, hematopoietic stem cells, HSCs, immunotherapy, Innovation, leukemia, lymphoma, research, T cells, T lymphocytes, tumor, tumor cells

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In the first part of this series we introduced the concept of cell-based immunotherapy with T cell transplants. Next, we describe an even more potent approach to cancer treatment with T cells that are engineered to express anti-tumor molecules or cell surface tumor-identifying killer receptors. The latter of which are called chimeric antigen receptors, or CARs.

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Will T Cells Be the Future Basis of Cancer Therapy?

Mar 12, 2014 6:00:07 AM / by Maria posted in antibodies, Bone marrow, cancer, Cancer Immunology, cell therapy, chemotherapy, cord blood, drug development, Innovation, PBCs, Peripheral blood cells, peripheral blood mononuclear cells, research, stem cell therapy, stem cells, T cells, T lymphocytes, tumor

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Recent data suggest that the average person has about a 40% chance of developing cancer at some point in his or her lifetime. [1] If those statistics are not frightening enough, let’s talk treatment: chemotherapy, radiation, surgery, chemical-based drug therapy, or a combination of the above. And don’t forget the various side effects of cancer therapy, many of which are a result of the destruction of crucial adult stem cells in the body. Because of this, stem cell transplants have been performed with fresh stem cells originating from bone marrow, peripheral blood, or cord blood to help replenish a patient’s hematopoietic system.

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Peripheral Blood Mononuclear Cells (PBMCs) in Cancer Drug Discovery and Development

Jan 30, 2014 3:00:06 PM / by Maria posted in aging, cancer, cancer drug assay, chemotherapy, drug development, drug discovery, drug screening, Innovation, PBCs, PBMCs, Peripheral blood cells, peripheral blood mononuclear cells, research, tumor

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In Part II of this series we discussed how peripheral blood mononuclear cells can be used to screen for drugs responses in healthy and infected cells. Here we discuss other measurements that are particularly useful in the context of cancer drug discovery and development.

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