Blog | HemaCare

Prevent Recurring Tumors with Immunotherapy

May 14, 2018 10:13:00 AM / by Stacy Matthews Branch, DVM, PhD posted in new immunotherapy advances, cancer immunotherapy, Dendritic Cell Immunotherapy, Dendritic cells, immunotherapy, tumor cells, Tumors

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Immunotherapy is becoming a promising treatment approach for cancer patients with recurring tumors, and more studies will help to further develop the treatment options.

Surgical resection is still the first-line treatment for solid tumors despite the rate of tumor recurrence with this approach. Surgery to remove tumors provokes wound healing processes that promote local immunosuppressive environments and metastasis. Surgical resection of tumors can also remove beneficial immune cells and factors that could promote targeting and killing of tumor cells. Radio- or chemotherapy as an adjunct to surgery has some limited effects on distant metastasis, but these treatments are associated with significant systemic adverse effects. 

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Anti-Tumor Immunity Can Be Induced by Dendritic Cells Fused with Tumor-derived Endothelial Cells

May 17, 2017 10:04:40 AM / by Stacy Matthews Branch, DVM, PhD posted in bioresearch, Dendritic cells, research, tumor cells

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Dendritic cells are powerful antigen-presenting cells that are crucial for immune responses including those against tumor cells. These cells process and present invading and disease-causing cells and molecules to T cells. When dendritic cells fuse with tumor antigens, T cells are activated to induce anti-tumor immunity.

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Next Generation Leukemia Immunotherapy: New Hope for Leukemia Treatment

Sep 17, 2014 1:00:58 PM / by Shweta posted in cancer, Cancer Immunology, cancer immunotherapy, Innovation, leukemia, research, T lymphocytes, tumor cells

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New mode of cancer cell recognition by the immune system opens up a new gateway for leukemia immunotherapy

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CAR-Expressing T Cells: Driving the Express Track to Cancer Immunity

Mar 19, 2014 6:10:31 AM / by Maria posted in cancer, Cancer Immunology, cancer immunotherapy, cell therapy, chemotherapy, drug development, hematopoietic stem cells, HSCs, immunotherapy, Innovation, leukemia, lymphoma, research, T cells, T lymphocytes, tumor, tumor cells

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In the first part of this series we introduced the concept of cell-based immunotherapy with T cell transplants. Next, we describe an even more potent approach to cancer treatment with T cells that are engineered to express anti-tumor molecules or cell surface tumor-identifying killer receptors. The latter of which are called chimeric antigen receptors, or CARs.

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Turning T cells on: Switch Stimulates Tumor Removal

Dec 12, 2013 9:25:32 AM / by Maria posted in cytotoxic T cells, PBMCs, peripheral blood mononuclear cells, research, T lymphocytes, tumor cells

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Independent study uses peripheral blood mononuclear cells (PBMCs) from HemaCare to investigate co-stimulatory molecules to effector T cells.

 
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