Blog | HemaCare

New Progress in Immunotherapy Strategies

Apr 23, 2018 10:02:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Cancer, CAR-T, Dendritic Cells, Vaccine Research, Immunotherapy (Immunology)

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State-of-the-art immunotherapies may show great promise in the future for cancer treatment.

Immunotherapy research results show that cancer treatment may need a combination approach. Dr. Andrew S. Chi, the chief of neuro-oncology and the codirector of the Brain Tumor Center at NYU Langone, weighed in on the state of developed immunotherapy approaches. A number of strategies involve increasing T-cell activation against tumors by the use of checkpoint inhibitors (that block proteins that inhibit immune system attack of cancer cells). Dr. Chi points out that combinations of immune checkpoint inhibitors may be more effective. 

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Improved Cancer Immunotherapy Possible with Dendritic Cell Vaccines

Apr 2, 2018 10:11:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Dendritic Cells, Vaccine Research

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Personalized dendritic cell vaccines have continued to show success with the treatment of certain cancers. 

Dendritic cell vaccines are increasingly showing success in the treatment of certain cancers. Dendritic cells are antigen-presenting cells that process antigens then present them to T cells. In the personalized approach to using dendritic cells vaccines, cells are obtained from the patient, exposed or loaded with cancer antigens, and grown. The resulting antigen-loaded dendritic cells are injected back into the patient, where the dendritic cells can elicit the anti-cancer immune response of T cells.

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Plasmonic Nano Vectors Can Activate Dendritic Cells

Aug 25, 2017 12:23:31 PM / by Stacy Matthews Branch, DVM, PhD posted in Cancer, Dendritic Cells, Vaccine Research

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Conventional cancer treatment strategies are toxic to normal cells and lead to severe adverse effects for patients with cancer. To avoid exposure of chemotherapeutic agents to healthy tissue, controlled delivery of drugs targeting only tumor tissue would have significant clinical value. Research efforts in developing nanotechnology-based delivery systems can provide significant cancer treatment options; however, the choice of materials is crucial for their efficacy and safety.

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Dendritic Cells for Immunotherapy

Mar 15, 2017 6:07:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Dendritic Cells, Vaccine Research

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Immunotherapy uses natural body defenses to fight diseases such as cancer. There are immunotherapy approaches that involve the use of dendritic cells, cells that present antigens to T cells for destruction. Dendritic cells earned the name of “natural adjuvants” because of their special and potent antigen presenting function. When dendritic cells come in contact with an antigen, they engulf or take up the antigen. The antigen is then processed for presentation to CD8+ cytotoxic T cells. This activates the T cells to begin the process of antigen deactivation and killing.

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HPV-Pulsed Dendritic-Cell Vaccination in a Patient with Metastatic Cervical Cancer

Mar 1, 2017 9:29:35 AM / by Stacy Matthews Branch, DVM, PhD posted in bioresearch, Dendritic Cells, Vaccine Research

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The diagnosis and treatment of inoperable cervical carcinoma severely affects the quality of life of patients and their caregivers. The one-year survival rate remains under 15%. Dendritic cells have been studied as adjuvants that modify the effects of tumor immunotherapy in humans. A case report has been published that describes the vaccination with dendritic cells of a patient with metastatic cervical cancer.

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