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Tumor Cell–Loaded Dendritic Cells Improve Adoptive T-Cell Therapy

Dec 19, 2016 12:00:00 AM / by Stacy Matthews Branch, DVM, PhD posted in Cancer, Dendritic Cells, Vaccine Research, Basic Research

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Tumor-specific cytotoxic T cells are used in patients with cancer with the goal of providing specific recognition and destruction of tumor cells. In adoptive T cell therapy, tumor-specific T cells are collected and multiplied (expanded) outside the body. This is done to obtain a much larger number of the tumor-specific T cells that the patient can be treated with more successfully.

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Dendritic Cell Cancer Vaccine in the Pipeline

Oct 6, 2016 9:40:31 AM / by Stacy Matthews Branch, DVM, PhD posted in Cancer, Dendritic Cells, Vaccine Research

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Autologous (patient-specific) immunotherapy for acute myeloid leukemia will soon be tested in Phase III clinical trials in patients with acute myelogenous leukemia (AML, a cancer of the blood and bone marrow). Asterias (a regenerative medicine‒focused company) developed an autologous immunotherapy (AST-VAC1) designed to destroy tumor cells. AST-VAC1 immunotherapy is based on the use of a patient’s own dendritic cells to elicit immune system attack on telomerase. Telomerase is an enzyme that is expressed in stem cells and 95% of cancers, but it is rare or absent in normal adult cells.

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Vaccine + Antibody = Kill Cancer or Kill Tumor

Aug 31, 2016 1:30:31 AM / by Stacy Matthews Branch, DVM, PhD posted in Cancer, Cytotoxic T Cells, Tumors, Vaccine Research

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Antitumor combination therapy is a strategy to mount a more successful attack on tumor growth. Significant suppression of tumor growth by enhancing cytotoxic T cell activation can be achieved with the combined use of an antitumor vaccine and immune checkpoint antibody treatment. The function of cancer vaccines include stimulating the immune system to mount an attack against tumor cells, as well as enhancing cytotoxic T cell reactions. However, checkpoint antibodies are treatments designed to inhibit factors that prevent the function of cytotoxic T cells. These factors represent one of the main weaponry used by cancer cells against immune system attack.

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Dendritic Cells Role in Fighting Helminth Infection

Aug 10, 2016 9:42:46 AM / by Stacy Matthews Branch, DVM, PhD posted in Dendritic Cells, Stem Cells, Uncategorized, Vaccine Research, Basic Research

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Helminth (parasitic worm) infection continues to pose health threats to people worldwide. The immune system (the body’s natural defense) plays an important role in fighting helminth infections. A key component of this immune function is the dendritic cell. Dendritic cells process and present disease-causing invaders to the immune system cells that can act to destroy or eliminate them. Dendritic cells are messengers between the two types of immune systems innate (rapid nonspecific immune response) and adaptive (specialized response). Given this function, dendritic cells are often referred to as “professional” antigen-presenting cells. 

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A Cure for Hepatitis C, But What About Hepatitis B?

Nov 11, 2015 1:00:52 PM / by Maria posted in Vaccine Research, Infectious Disease

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Hepatitis B can be as serious as hepatitis C. Researchers may be on the heels of a cure.

The "C" in Hepatitis C could stand for "chronic," or "cancer forming" -- or, these days, "curable." Most people who are exposed to the virus that causes Hepatitis C develop a chronic infection of the liver. A myriad of health problems can ensue, including scarring of the liver, cirrhosis, liver cancer, and liver failure. The numbers are staggering: 150-250 million people in the world are living with chronic hepatitis C. A total of 340,000 liver cancer deaths due to hepatitis C occurred in 2013; an additional 360,000 people died of cirrhosis.

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