Blog | HemaCare

Stem Cell Test to Determine Cytokine Release Syndrome Ahead of Time

Jun 22, 2015 1:00:31 PM / by Shweta posted in drug screening, PBMCs, Stem Cells, T lymphocytes, white blood cells, Whole Blood, Basic Research

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Another potential application of human stem cells is to recognize side effects of drugs

Biological therapy is a form of treatment that uses biological materials such as antibodies and stem cells. Several biological therapies, including monoclonal antibodies, are now well established as part of the treatment for many diseases such as cancer, transplant rejection, autoimmune disorders, and infections. Personalized medicine is now a key emerging technology in drug development. However, they can cause adverse side effects in humans. Therefore, biologic therapies require the use of human tissue-based bioassays to measures the efficacy and safety of the drug.

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Can Multiplex Gene Expression Analysis Go Faster? Whole Blood from HemaCare Helped Show That it Can

May 25, 2015 1:00:33 PM / by Maria posted in Assay Development, Cancer, Whole Blood, Basic Research

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Researchers use novel technology that skips the RNA isolation step. Whole blood provided by HemaCare was important in demonstrating the approach.

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Experimental Blood Therapy May Cure Ebola

Feb 9, 2015 1:00:56 PM / by Shweta posted in Whole Blood, Plasma, Infectious Disease, Basic Research

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Convalescent plasma therapy could be an effective treatment to fight against the Ebola virus

The Ebola virus causes a serious and deadly disease transmitted by animals and humans. The current Ebola epidemic is the largest outbreak in history, affecting many countries in West Africa. The Ebola virus likely originated in African fruit bats, but apart from zoonotic transmission it can also be transmitted from one human to another via direct contact such as through broken skin or mucous membranes, bodily secretions or fluids, or by contact with surfaces and materials (e.g. bedding, clothing) contaminated with these fluids. So far, no FDA-approved vaccine or medicine is available to treat Ebola infection. Only a few primary prevention measures are available which are largely based on symptomatic treatment and by avoiding direct contact with infected people and animals.

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Tregs opens up Exciting Opportunities for Cell Based Therapies

Sep 22, 2014 1:00:40 PM / by Shweta posted in Cell Therapy, Regulatory T Cells, Whole Blood, GMP Cellular Therapeutics, Basic Research

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Manufacturing of clinical grade Tregs for cell based therapies

Graft-versus-host disease (GVHD) is a grave matter of concern for allogeneic hematopoietic stem cell transplantation (HSCT) where newly transplanted donor cells regard the recipient's body as foreign and attack them. This life-threatening complication is due to the fact that donor T-cells, present within the transplant recognize recipient major and/or minor histocompatibility antigens, become activated and attack target organs of GVHD. Although a variety of pharmacologic agents are available, such as calcineurin inhibitors and steroids to boost the tolerance against the clinical transplantation still more than 50% of severe GVHD patients are refractory to these current therapies[1]. Moreover, the long-term use of such agents impairs immune reconstitution, and diminishes T-cell mediated graft-versus-leukemia (GVL) responses. Therefore, there is a pressing need to develop specific cell-based therapies which may offer alternative approaches to prevent and/or to control severe GVHD.

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Proteome of the Human Blood

Jun 18, 2014 1:00:07 PM / by Maria posted in Peripheral blood cells, white blood cells, Whole Blood, Basic Research

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Several omics data such as genomics and transcriptomics, have been available for several tissues, including the blood. Now, for the first time we have access to the proteome of human blood.

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