Blog | HemaCare

Genome Editing in Hematopoietic Stem and Progenitor Cells Just Got Easier

Jan 18, 2016 1:00:20 PM / by Karina Palomares posted in CD34, hematopoietic stem cells, stem cells, zinc finger nucleases

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Researchers at USC and Sangamo Biosciences have developed a more efficient genome editing method for HSPCs.

Gene therapy using hematopoietic stem and progenitor cells (HSPCs) has great potential for treating HIV and other diseases of the blood and immune system. One application of gene therapy that is close to clinical translation is the disruption of the HIV-1 co-receptor, CCR5, to engineer cells that are resistant to HIV infection.   While promising, the genome editing process isn’t perfect, so only some of the cells end up carrying the desired modification. HSPCs are relatively rare populations that are quiescent, which makes it difficult to transfer genes into these cells with high efficiency. In addition, correction of a mutation or insertion of new DNA sequences at a specific location is often challenging.

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The Microbiome Knows a Colon Cancer's Secrets -- and It's Talking

Dec 9, 2015 1:00:52 PM / by Maria posted in microbiome, research, whole exome sequencing, zinc finger nucleases

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The mutational status of a colon cancer tumor affects the nearby bacteria, which can be analyzed non-invasively.

When you live in close quarters with roommates, you can't help but be affected by their actions. If they drink all the coffee, for example, you might go into some serious caffeine withdrawal.

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Gene Editing in Stem Cells Corrects a Troubling Disorder

Aug 13, 2014 1:00:41 PM / by James Sanchez posted in CD34, immune system, Innovation, research, stem cells, T cells, zinc finger nucleases

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By targeting a defective gene in stem cells, researchers opened a new possibility in correcting genetic disorders.

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