Peripheral blood mononuclear cells (PBMCs) are peripheral blood cells containing a round nucleus. Examples of these types of cells include the various types of lymphocytes (including T cells) and monocytes. These are different from other blood cells that contain multi-lobed nuclei (e.g., neutrophils and eosinophils) and those that have no nucleus such as platelets and red blood cells (erythrocytes).
Blood tests are routinely done to measure the number, or level, of PBMCs in the blood to determine the overall state of health and the presence of disease, such as infections. It is now recognized that the PBMC count can be related to cardiovascular disease, bone health, and cancer outcomes. However, the study of PBMCs has more than diagnostic value. Peripheral blood mononuclear cells have the ability to change into various cell types, including smooth muscle cells (such as those found in the heart), bone producing cells (osteoblasts), red blood cells, and even neural cells. This gives utility for therapies to help regenerate tissues, as a treatment for hematologic malignancies (such as multiple myeloma), and as a means to fight infections.
A clinical trial is planned in order to collect human PBMCs from healthy volunteers to perform research studies on the development of therapies that use a person’s own immune system cells to combat tumors. The idea behind the clinical trial is to collect human PBMCs (from adults 18 to 99 years of age) and use these cells for the expansion of T cells collected from patients with cancer. That is, the healthy PBMCs will be cultured (grown in the laboratory) with the T cells taken from patients with cancer. The goal is to use this culture technique to grow more of the patient’s T cells at a level needed for T cell therapy. The grown T cells can then be used to treat the patient from whom the original T cells originated. This form of therapy is a personalized medical approach that can potentially improve immunity against tumors. New and emerging molecular methods enhance the potential therapeutic success of adoptive T cell therapy approaches.
At HemaCare, we offer purified PBMC’s for your research needs. If you have any questions or would like to place an order, please call (877) 397-3087.
"Collection Of Peripheral Blood Mononuclear Cells (Pbmcs) From Healthy People For The Expansion Of T Cells For Adoptive Cell Therapy". Bioportfolio.com. N.p., 2016. Web. 17 Aug. 2016.